3．4糖尿病研究糖尿病的实验中，Annexin Ⅰ, Annexin Ⅱ以及大量细胞骨架重建蛋白可与质膜结合形成葡萄糖加合物，这种糖基化作用会改变内皮细胞膜的流动性［24］. 另有研究表明在体外培养的大动脉内皮细胞表面，大量葡萄糖会诱导Hsp90与Annexin Ⅱ结合. Annexin Ⅱ在纤溶系统中生理功能会因这种变化无法正常发挥，从而引起糖尿病的并发症血栓形成，导致许多糖尿患者死亡［25］. 另外依赖胰岛素和肌动蛋白的转糖体GLUT4在脂肪细胞中的转运作用也需要Annexin Ⅱ辅助，若Annexin Ⅱ表达失调，会间接促进糖尿病及其各种并发症发生.
4总结
对Annexin Ⅱ的研究可追溯到20世纪80年代，二十年时间里，对该蛋白的认识不断更新. 对Annexins家族的病理研究进步显著以至于有了annexinopathies的概念［26］，这充分显示了该家族蛋白在机体中的重要地位. 但是仍有很多问题有待解决，例如，Annexin Ⅱ分泌的确切机制，它在癌症中究竟扮演了什么样的角色，是否可以提供新的药物治疗靶点等都还需要深入细致的研究.
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